Catalytic asymmetric oxidation of sulfides to sulfoxides using (R)-6,6′-Diphenyl-BINOL as a chiral ligand
NAROTHAM V MADDIREDDY HIMANSHU M GODBOLE GIRIJ P SINGH SUVARNA G KINI GAUTHAM G SHENOY
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The chiral metal complex produced in situ from (R)-6,6′-Diphenyl-BINOL and Ti(O−i−Pr)4 as a catalytic system for asymmetric sulfoxidation of aryl methyl and aryl benzyl sulfides in the presence of 70% aqueous TBHP as the oxidant has been investigated. The influence of variation of reagents mole ratios, temperature, solvent and oxidant was examined, and the optimized conditions were then used to oxidize a number of aryl methyl and aryl benzyl sulfides, producing sulfoxides in high enantiopurities (up to 90% ee) and good yields (up to 81%).
NAROTHAM V MADDIREDDY1 HIMANSHU M GODBOLE1 GIRIJ P SINGH1 SUVARNA G KINI2 GAUTHAM G SHENOY2
Volume 135, 2023
Continuous Article Publishing mode
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