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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/131/07/0064

    • Keywords

       

      (R)-6,6′-Diphenyl-BINOL; enantiopure sulfoxides; chiral ligand

    • Abstract

       

      The chiral metal complex produced in situ from (R)-6,6′-Diphenyl-BINOL and Ti(O−i−Pr)4 as a catalytic system for asymmetric sulfoxidation of aryl methyl and aryl benzyl sulfides in the presence of 70% aqueous TBHP as the oxidant has been investigated. The influence of variation of reagents mole ratios, temperature, solvent and oxidant was examined, and the optimized conditions were then used to oxidize a number of aryl methyl and aryl benzyl sulfides, producing sulfoxides in high enantiopurities (up to 90% ee) and good yields (up to 81%).

    • Author Affiliations

       

      NAROTHAM V MADDIREDDY1 HIMANSHU M GODBOLE1 GIRIJ P SINGH1 SUVARNA G KINI2 GAUTHAM G SHENOY2

      1. Lupin Limited, 46 & 47A, Village Nande, Taluka Mulshi, Pune, Maharashtra 412 115, India
      2. Manipal Academy of Higher Education, Manipal, Karnataka 576 104, India

    • Dates

       
      Published
      July 2019
      Manuscript received
      8 February 2019
      Manuscript revised
      26 April 2019
      Accepted
      3 May 2019

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