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      https://www.ias.ac.in/article/fulltext/jcsc/131/06/0045

    • Keywords

       

      Meldrum’s acid; cyclization; 5-HT; SSRI

    • Abstract

       

      A new group of serotonin reuptake inhibitors containing 1,2-dihydrocyclopenta[b]indol-3(4H)-one scaffoldwas synthesized, starting from indole 5-((1H-indol-3-yl)(1,3-dioxane-4,6-diones as a key intermediates.Following three transformations including intramolecular cyclization and formation of imines, a series of new ligand for human serotonin transporter was obtained. The ability of these ligands to inhibit human TS3 serotonin transporter as well as selectivity toward human D3 dopamine receptor and dopamine transporter were tested in silico using docking software.

    • Author Affiliations

       

      MILENA SZEWCZYK PAWEŁ PUNDA KAROLINA JANIKOWSKA SłAWOMIR MAKOWIEC1

      1. Department of Organic Chemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gda´nsk, Poland
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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