• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/131/04/0027

    • Keywords

       

      1, 2, 3-Triazoles; antifungal; flutriafol analogues.

    • Abstract

       

      A small library of diverse 1,1-diaryl-2-(1,2,3)triazol-1-yl-ethanol derivatives was designed and prepared from CuAAC reaction as the key step. The molecular structure of some representative compounds was unambiguously determined from X-ray diffraction studies. In addition, synthesized 1,2,3-triazoles wereevaluated for activity against filamentous fungi (Mucor hiemalis, Aspergillus fumigatus, Trichosporon cutaneum, and Rhizopus oryzae) and yeasts that belong to the genus Candida. Two compounds showed high activity against C. utilis (MIC 0.5 μg/mL) and A. fumigatus (MIC 4 μg/mL) which is close to itraconazole used as reference compound.

    • Author Affiliations

       

      JUAN JOSÉ GARCÍA-VANEGAS1 ALEJANDRA RAMÍREZ-VILLALVA2 AYDEÉ FUENTES-BENITES2 DIEGO MARTÍNEZ-OTERO1 NELLY GONZÁLEZ-RIVAS1 ERICK CUEVAS-YAÑEZ1

      1. Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Universidad Autónoma del Estado de México, Carretera Toluca-Atlacomulco Km 14.5, 50200 Toluca, Estado de México, Mexico
      2. Departamento de Química Orgánica, Facultad de Química, Universidad Autónoma del Estado de Mexico, Paseo Colon/Paseo Tollocan s/n, 50120 Toluca, Mexico
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

© 2021-2022 Indian Academy of Sciences, Bengaluru.