• Sequential Michael addition/retro-Claisen condensation of 1,3-diarylpropan-1,3-diones with nitrostyrenes: one-step synthesis of 4-nitro-1,3-diarylbutan-1-ones

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      https://www.ias.ac.in/article/fulltext/jcsc/131/04/0026

    • Keywords

       

      Michael addition; retro-Claisen condensation; γ-nitro ketone; carbon-carbon bond formation; carbon-carbon bond cleavage

    • Abstract

       

      The sequential Michael addition/retro-Claisen condensation of 1,3-diarylpropan-1,3-diones with nitrostyrenes is described. 4-Nitro-1,3-diarylbutan-1-ones were efficiently synthesized in good to high yield under mild, transition-metal-free condition. This one-step method involving sequential carbon-carbon bond formation and cleavage provides a good alternative to the synthesis of various γ-nitro ketones.

    • Author Affiliations

       

      ZHENG LI1 HAO LU ZHENRONG LIU XIAOLONG MA

      1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, Gansu, People’s Republic of China
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  • Journal of Chemical Sciences | News

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