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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/131/03/0022

    • Keywords

       

      Proline; mandelic acid; tartaric acid; chiral phase transfer catalysts; enantioselective epoxidation; Darzen condensation.

    • Abstract

       

      Herein, we have described the synthesis of novel chiral cyclic phase transfer catalysts (PTCs). These catalysts are synthesized from proline, mandelic acid and tartaric acid by using simple synthetic methods with competitive yields. These chiral cyclic phase transfer catalysts have been characterized by 1H NMR and 13C NMR spectroscopy, IR spectroscopy and elemental analysis. The effectiveness of these novel chiral cyclic phase transfer catalysts was evaluated by applying them in the enantioselective epoxide synthesis from α, β unsaturated ketone (chalcone) and Darzens condensation. The obtained results show that the synthesized derivatives of proline, mandelic acid and tartaric acid are effectual as PTCs.

    • Author Affiliations

       

      DEEPAK P MAHAJAN1 HIMANSHU M GODBOLE1 GIRIJ P SINGH1 GAUTHAM G SHENOY2

      1. Lupin Limited, 46 & 47A, Village Nande, Taluka Mulshi, Pune, Maharashtra 412 115, India
      2. Manipal Academy of Higher Education, Manipal, Karnataka 576 104, India

    • Dates

       
      Published
      March 2019
      Manuscript received
      6 November 2018
      Manuscript revised
      24 December 2018
      Accepted
      29 January 2019

    • Supplementary Material

       

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