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      https://www.ias.ac.in/article/fulltext/jcsc/131/02/0009

    • Keywords

       

      Iron(III) complexes; amino acid; photocytotoxicity; photo-activation; ROS generation.

    • Abstract

       

      Several amino acid-based photo-active monomeric iron(III) complexes of the general formula,[Fe(L)2]PP-, where L= Schiff base ligands (salisalidene arginine, salicylidenetryptophan, 3,5-di-tert-butyl benzalidine arginine and salicylidene tryptophan) were synthesized, characterized and explored for photoactivated anticancer activity to Chang Liver Cells, HeLa and MCF-7 cells. Complexes exhibited remarkable photo-cytotoxicity with IC50 value to the extent of 0.7 μM to Chang Liver Cells in visible light and there wasa 40-fold enhancement in cytotoxicity in comparison to the cytotoxicity in dark. Complexes were non-toxic to MCF-10A (normal cells) in dark and visible light (IC50 > 100 μM in dark; IC50 > 80 μM in visible light) signifying target-specific nature of the anti-tumour activity of the complexes. Increased ROS concentration,as probed by DCFDA assay, in the cancer cells was responsible for apoptotic cell death. Decarboxylation or phenolate-Fe(III) charge transfer of photo-activated iron(III) complexes generating • OH radicals (ROS) were responsible for the apoptosis. Overall, the tumour-selective photo-activated anticancer activity of the amino acidbased iron(III) complexes have shown a promising aspect in developing iron-based photo-chemotherapeutics as the next generation PDT agents.

    • Author Affiliations

       

      S BINITA CHANU1 MD KAUSAR RAZA2 SAMYA BANERJEE3 POOJA RANI MINA4 DULAL MUSIB1 MITHUN ROY1

      1. Department of Chemistry, National Institute of Technology Manipur, Langol, Imphal, Manipur 795 004, India
      2. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, Karnataka 560 012, India
      3. Department of Chemistry, John Hopkins University, 23400 N. Charles Street, Baltimore, MD 21218, USA
      4. Department of Molecular Bioprospection, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh 226 015, India
    • Dates

       
  • Journal of Chemical Sciences | News

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