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      https://www.ias.ac.in/article/fulltext/jcsc/130/12/0169

    • Keywords

       

      Nickel(II) complex; imidazole-4-acetate anion; antifungal; cytotoxicity.

    • Abstract

       

      The neutral mononuclear nickel(II) complex with an imidazole-4-acetate anion (iaa), having the formula [Ni(iaa)2(H2O)2]· H2O, was characterized by single-crystal X-ray diffraction, IR, farIR, UV-Vis-NIR spectra and magnetic measurements. The imidazole-4-acetate anion in this complex is a chelating ligand where an azomethine nitrogen atom of the imidazole ring and carboxylate oxygen atoms are donor atoms. The immediate environment of the central nickel(II) ion is described by distorted cis-octahedron (NiN2O4 chromophore). The analysis of biological properties of [ Ni(iaa)2(H2O)2]· H2O complex has shown that this complex at non-cytotoxic concentration against normal human BEAS-2B cell has antifungal properties. The biophysical studies have shown that of [[Ni(iaa2(H2O)2]·H2O] interacts with DNA without degradation and with BSA as a model protein.

    • Author Affiliations

       

      KATARZYNA GALCZYNSKA1 KRYSTYNA KURDZIEL2 KAROL CIEPLUCH1 JAROSLAW RACHUNA1 MAGDALENA KOWALSKA1 LUKASZ MADEJ3 ANETA WEGIEREK-CIUK4 ANNA LANKOFF4 5 MICHAL ARABSKI1

      1. Department of Biochemistry and Genetics, Institute of Biology, Jan Kochanowski University, ´ Swie.tokrzyska 15, 25-406 Kielce, Poland
      2. Institute of Chemistry, Jan Kochanowski University, ´ Swie.tokrzyska 15G, 25-406 Kielce, Poland
      3. Holycross Cancer Center, Artwi´ nskiego 3, 25-734 Kielce, Poland
      4. Department of Radiobiology and Immunology, Jan Kochanowski University,´ Swie.tokrzyska 15, 25-406 Kielce, Poland
      5. Center for Radiobiology and Biological Dosimetry, Institute of Nuclear Chemistry and Technology, Dorodna 16, 03-195 Warsaw, Poland
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