• Pot-economic synthesis of diarylpyrazoles and pyrimidines involving Pd-catalyzed cross-coupling of 3-trifloxychromone and triarylbismuth

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      https://www.ias.ac.in/article/fulltext/jcsc/130/12/0165

    • Keywords

       

      Cross-coupling; triarylbismuth; isoflavones; diarylpyrazoles; diarylpyrimidines; pot-economy

    • Abstract

       

      The present study reveals the formation of 3,4-diarylpyrazole and 4,5-diarylpyrimidine in one-pot operation starting from 3-trifloxychromone and triarylbismuth. The complete process encompasses two steps in the one-pot operation. The first step leads to the formation of isoflavone via cross-coupling reaction of 3-trifloxychromone and triarylbismuth as a threefold arylating reagent. These isoflavones were further converted into 3,4-diarylpyrazole and 4,5-diarylpyrimidine using hydrazine hydrate and guanidinium chloride in thesuccessive step in the same pot. Interestingly the formation of 3,4-diarylpyrazole was achieved in the shortest reaction time i.e., 30 min that too at room temperature. Overall the developed methodology provides easy accessto the medicinally important diarylpyrazole and pyrimidine moiety in one-pot operation and in short reaction time.

    • Author Affiliations

       

      ABHIJEET KUMAR1 2 MADDALI L N RAO2

      1. Department of Chemistry, School of Physical and Material Sciences, Mahatma Gandhi Central University, Motihari, Bihar 845 401, India
      2. Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208 016, India
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