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      https://www.ias.ac.in/article/fulltext/jcsc/130/11/0151

    • Keywords

       

      C6-olefination of DHPMs; vinylogous aldol condensation; ferric chloride; dihydropyrimidinones

    • Abstract

       

      Herein, we describe a practical approach for direct vinylogous aldol condensation of Biginelli product for carbon–carbon double bond formation at methyl group of 6-methyl dihydropirimidinone by using hydrated ferric chloride. With aromatic aldehydes, the method yields stereoselectively trans products. The olefination reaction is applicable with aldehyde without chelating (with Fe III) functional group. DHPMs with carboxylate ester and arylidene at C-6 methyl are not known. The method opens up a new avenue for the synthesis of a wide variety of DHPMs. The olefin products were subjected to dihydroxylation reaction.

    • Author Affiliations

       

      MOHABUL A MONDAL1 2 ABDUL ASHIK KHAN2 KANCHAN MITRA2

      1. Department of Chemistry, Jadavpur University, Kolkata, West Bengal 700 032, India
      2. Department of Chemistry, University of Gour Banga, Malda, West Bengal 732 103, India
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