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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/130/09/0127

    • Keywords

       

      Combretastatin; candenatenin E; chromene; resveratrol; Wittig reaction; cytotoxicity; antimitotic activity; chromene.

    • Abstract

       

      Abstract. Two new series of compounds (Z/E)-2-phenyl/H-3-Styryl-2H-Chromenes 9(a-r) and 10(a-s)were synthesized and evaluated in vitro cytotoxic activities against four cancer cell lines. One compound, Z)-8-ethoxy3-(4-methoxystyryl)-2-phenyl-2H-chromene (9g) was found to be the most active among the tested compounds in HeLa cell lines (IC5010μM). Compound 9g arrested cells at G2/M phase, disrupted microtubule network, accumulated tubulin in the soluble fraction and manifested an increased expression of the G2/M marker, Cyclin B1

    • Author Affiliations

       

      P PANDA1 S NAYAK1 S BHAKTA1 S MOHAPATRA1 T R MURTHY2

      1. Department of Chemistry, Ravenshaw University, Cuttack 753 003, Odisha, India
      2. Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, Telangana, India
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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