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      https://www.ias.ac.in/article/fulltext/jcsc/130/09/0125

    • Keywords

       

      Double contrast agents; silica nanoparticles; longitudinal relaxivity; transverse relaxivity

    • Abstract

       

      Abstract. In the present work, we have prepared the ~10 nm superparamagnetic iron-oxide nanoparticles by means of high-temperature decomposition of iron oleate precursor. Then they were coated with silica shell to impart water-solubility and an ability to accommodate paramagnetic Gd(III)-based complexes inside silica coating. All of the prepared nanoparticles form stable in time aqueous dispersions and show good negative or/and positive contrasting effect at different magnetic field strengths (0.47, 1.41, 14.1 T). It has been also exemplifiedthat the incorporation of [Gd(TCAS)] complexes into silica shell triggers a significant increase of the transverse relaxivity of the core–shell nanoparticles. The correlation between relaxometric properties and morphology ofthe obtained nanoparticles was revealed. The non-toxicity of the obtained nanoparticles along with their ability to shorten both transverse and longitudinal relaxation rates of water protons make them good candidates for their use as dual-mode contrast agents in MRI.

    • Author Affiliations

       

      ALEXEY STEPANOV1 SVETLANA FEDORENKO1 RUSTEM AMIROV2 IREK NIZAMEEV3 KIRILL KHOLIN1 ALEXANDRA VOLOSHINA1 ANASTASIYA SAPUNOVA1 RAFAEL MENDES4 MARK RÜMMELI5 6 4 THOMAS GEMMING4 ASIYA MUSTAFINA1 BORIS ODINTSOV7 8

      1. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov Str., 8, Kazan, Russia 420088
      2. Kazan (Volga region) Federal University, Kremlyovskaya Str., 18, Kazan, Russia 420008
      3. Kazan National Research Technological University, Kazan, Russia 420015
      4. IFW Dresden, Helmholtz Strasse 20, 01069 Dresden, Germany
      5. Soochow Institute for Energy and Materials Innovations, College of Physics, Optoelectronics and Energy & Collaborative Innovation Center of Suzhou Nano Science and Technology & Suzhou Key Laboratory for Advanced Carbon Materials and Wearable Energy Technologies, Soochow University, Suzhou 215006, China
      6. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, M. Curie-Sklodowskiej 34, 41-819 Zabrze, Poland
      7. Biomedical Imaging Center of the Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign IL 61801, USA
      8. Department of Bioengineering, University of Illinois, Urbana-Champaign IL 61801, USA
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    • Supplementary Material

       
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