Silica-coated iron-oxide nanoparticles doped with Gd(III) complexes as potential double contrast agents for magnetic resonance imaging at different field strengths
Abstract. In the present work, we have prepared the ~10 nm superparamagnetic iron-oxide nanoparticles by means of high-temperature decomposition of iron oleate precursor. Then they were coated with silica shell to impart water-solubility and an ability to accommodate paramagnetic Gd(III)-based complexes inside silica coating. All of the prepared nanoparticles form stable in time aqueous dispersions and show good negative or/and positive contrasting effect at different magnetic field strengths (0.47, 1.41, 14.1 T). It has been also exemplifiedthat the incorporation of [Gd(TCAS)] complexes into silica shell triggers a significant increase of the transverse relaxivity of the core–shell nanoparticles. The correlation between relaxometric properties and morphology ofthe obtained nanoparticles was revealed. The non-toxicity of the obtained nanoparticles along with their ability to shorten both transverse and longitudinal relaxation rates of water protons make them good candidates for their use as dual-mode contrast agents in MRI.
ALEXEY STEPANOV1 SVETLANA FEDORENKO1 RUSTEM AMIROV2 IREK NIZAMEEV3 KIRILL KHOLIN1 ALEXANDRA VOLOSHINA1 ANASTASIYA SAPUNOVA1 RAFAEL MENDES4 MARK RÜMMELI5 6 4 THOMAS GEMMING4 ASIYA MUSTAFINA1 BORIS ODINTSOV7 8
Volume 133, 2021
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