Silica-coated iron-oxide nanoparticles doped with Gd(III) complexes as potential double contrast agents for magnetic resonance imaging at different field strengths
ALEXEY STEPANOV SVETLANA FEDORENKO RUSTEM AMIROV IREK NIZAMEEV KIRILL KHOLIN ALEXANDRA VOLOSHINA ANASTASIYA SAPUNOVA RAFAEL MENDES MARK RÜMMELI THOMAS GEMMING ASIYA MUSTAFINA BORIS ODINTSOV
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Abstract. In the present work, we have prepared the ~10 nm superparamagnetic iron-oxide nanoparticles by means of high-temperature decomposition of iron oleate precursor. Then they were coated with silica shell to impart water-solubility and an ability to accommodate paramagnetic Gd(III)-based complexes inside silica coating. All of the prepared nanoparticles form stable in time aqueous dispersions and show good negative or/and positive contrasting effect at different magnetic field strengths (0.47, 1.41, 14.1 T). It has been also exemplifiedthat the incorporation of [Gd(TCAS)] complexes into silica shell triggers a significant increase of the transverse relaxivity of the core–shell nanoparticles. The correlation between relaxometric properties and morphology ofthe obtained nanoparticles was revealed. The non-toxicity of the obtained nanoparticles along with their ability to shorten both transverse and longitudinal relaxation rates of water protons make them good candidates for their use as dual-mode contrast agents in MRI.
ALEXEY STEPANOV1 SVETLANA FEDORENKO1 RUSTEM AMIROV2 IREK NIZAMEEV3 KIRILL KHOLIN1 ALEXANDRA VOLOSHINA1 ANASTASIYA SAPUNOVA1 RAFAEL MENDES4 MARK RÜMMELI5 6 4 THOMAS GEMMING4 ASIYA MUSTAFINA1 BORIS ODINTSOV7 8
Volume 135, 2023
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