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      https://www.ias.ac.in/article/fulltext/jcsc/130/09/0120

    • Keywords

       

      Annulation reaction; isocoumarins; alkynes; ruthenium(II) catalyst; regioselection.

    • Abstract

       

      Heterocyclic compounds containing pyrrole and indole-fused isocoumarins were obtained from a one-pot synthesis via annulations of N-heterocyclic carboxylic acids and alkynes with N^O chelate ruthenium(II)complex, [RuCl(PySO3)(p-cymene)] (PySO3 = 2-pyridinesulfonate) in the presence of Cu(OAc)2H2O. The reaction proceeds efficiently in DMF but can also be performed in other solvents such as dichloroethane, tAmOH, and water. The annulations reaction is regioselective when performed 1-methylpyrrole-2-carboxylic acid with 1-phenyl-1-propyne.

    • Author Affiliations

       

      KEISHAM S SINGH1 SNEHA G SAWANT1 WERNER KAMINSKY WERNER KAMINSKY2

      1. Bioorganic Chemistry Laboratory, CSIR-National Institute of Oceanography, Dona Paula, Goa 403 004, India
      2. Department of Chemistry, University of Washington, Seattle, WA 98195, USA
    • Dates

       
    • Supplementary Material

       
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