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      https://www.ias.ac.in/article/fulltext/jcsc/130/09/0119

    • Keywords

       

      Benzothiophenes; heteroaromatic compounds; biological properties; antioxidant capacity; antimicrobial agents

    • Abstract

       

      Benzothiophene derivatives were synthesized regioselectively using coupling reactions and electrophilic cyclization reactions. Antimicrobial properties of isolated compounds were tested against indicator microorganisms such as C. albicans ATCC 10231, B. subtilis ATCC 6633, E. coli ATCC 25922 and S. aureusATCC 25923. 3-(4-aminobenzoethynyl)-2-(thiophen-2-yl) benzo[b]thiophene (12E), 3-ethynyl-2-(thiophen2-yl) benzo[b]thiophene (12L) and 3-(2-aminobenzoethynyl)-2-(thiophen-2-yl) benzo[b]thiophene (12J displayed high antibacterial activity against S. aureus. Further, 3-iodo-2-(thiophen-2-yl) benzo[b]thiophene (10) and 3-(trimethylsilylethynyl)-2-(thiophen-2-yl) benzo[b] thiophene (12K) were found to have potentials to be used as antifungal agents against current fungal diseases. Novel 3-(1H-indole-2-yl)-2-(thiophen-2-yl) benzo[b] thiophene (16) and 3-(4-aminobenzoethynyl)-2-(thiophen-2-yl) benzo[b] thiophene (12E) also showed quite high antioxidant capacities with TEAC values of 2.5 and 1.1, respectively; which surpassed the antioxidant capacity of an universally accepted reference of trolox.

    • Author Affiliations

       

      MUHEB A S ALGSO1 ARIF KIVRAK1 METIN KONUS2 CAN YILMAZ2 ASLIHAN KURT-KIZILDOGAN3

      1. Department of Chemistry, Van Yüzüncü Yil University, 65080 Van, Turkey
      2. Department of Molecular Biology and Genetics, Van Yüzüncü Yil University, 65080 Van, Turkey
      3. Department of Agricultural Biotechnology, Faculty of Agriculture, Ondokuz May.s University, Samsun 55139, Turkey
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