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      https://www.ias.ac.in/article/fulltext/jcsc/130/08/0114

    • Keywords

       

      Azo compounds; pyridinium quaternary salts; antibacterial activity; theoretical study.

    • Abstract

       

      The reaction of 2-hydroxy-5-(pyridine-4-yldiazenyl)benzaldehyde with n-alkyl bromides generated five novel azo pyridinium salts in good to excellent yields. The 1 H and 13 C NMR and UV-Vis absorption spectra indicated several tautomers for the new compounds. The NMR, UV-Vis absorption spectra and quantum chemical calculations show that the azo pyridinium salts have a new resonant structure compared to the corresponding azo precursor. Antibacterial activity was studied by disc diffusion and MIC methods. Diphenylpicrylhydrazyl(DPPH) assay was used to determine the antioxidant properties. The effects of carbon chain length on antimicrobial activity were also investigated. The results showed that existence of alkyl groups is crucial for the antibacterial properties. The new compound with decyl group displayed the best antibacterial activity.

    • Author Affiliations

       

      SAKINEH OMIDI1 VIDA KHOJASTEH1 ALI KAKANEJADIFARD1 MOTALEB GHASEMIAN1 FARIDEH AZARBANI2

      1. Department of Chemistry, Faculty of Science, Lorestan University, Khorramabad, Iran
      2. Department of Biology, Faculty of Science, Lorestan University, Khorramabad, Iran
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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