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    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/130/08/0107

    • Keywords

       

      Polyoxometalates; caprolactam; gels; cytotoxicity

    • Abstract

       

      Polyoxometalate (POM) based gels are synthesized by reacting POMs with an excess of caprolactam. These POM-entrapped caprolactam gels are thermoreversible and possess good mechanical strength. The gelation of POMs in caprolactam matrix brought the gel acidity similar to the physiological pH. The cytotoxicity studies on SCC 131 cell lines using these gels show 50% of cell death in the range of 2 to 6 mM concentration in 48 h. The supramolecular caprolactam matrix with active protons and the redox property of POMs are responsiblefor the cytotoxicity effect.

    • Author Affiliations

       

      K SHAKEELA1 G SILPA2 SURESH KUMAR RAYALA2 G RANGA RAO1

      1. Department of Chemistry, Indian Institute of Technology Madras, Chennai 600 036, Tamilnadu, India
      2. Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600 036, Tamilnadu, India

    • Dates

       
      Published
      August 2018
      Manuscript received
      26 April 2018
      Manuscript revised
      Accepted
      18 May 2018

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