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      https://www.ias.ac.in/article/fulltext/jcsc/130/07/0088

    • Keywords

       

      High-valent manganese; salen; hypochlorite; benzylic chlorination.

    • Abstract

       

      Metalloporphyrins are well-known to serve as the model for mimicking reactivities exhibited by cytochrome P450 hydroxylase. Recent developments on selective C–H halogenation using Mn-porphyrins provided the way for understanding the reactivity as well as mechanism of different halogenase enzymes. In this report, we demonstrated a method for benzylic C–H chlorination using easily prepared Mn(salen) complex as the catalyst, which shows a complementary reactivity of Mn-porphyrins. Here, NaOCl has been used as a chlorinating source as well as the oxidant. Efforts towards understanding the mechanism suggested the formation of the high-valent Mn(V)=O species which is believed to be the key intermediate to conduct this transformation.

    • Author Affiliations

       

      SHEULI SASMAL SUJOY RANA GOUTAM KUMAR LAHIRI1 DEBABRATA MAITI1

      1. Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra 400 076, India
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