1. Home
    2. Journals
    3. Journal of Chemical Sciences
    4. Volume 130
    5. Issue 6

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/130/06/0074

    • Keywords

       

      Isoindolinones; copper catalysis; deformylative C-N coupling; phenylboronic acid.

    • Abstract

       

      Copper(I) iodide efficiently catalyzes deformylative C-N coupling of formamides and isoindolinone3-ols to provide C(3) primary/secondary amine substituted isoindolinones. The transformation requires a stoichiometric amount of phenylboronic acid as a co-reactant. In the reaction, formamides act as the synthetic equivalent of primary/secondary amines. The method is amenable for the synthesis of a combinatorial library of medicinally relevant C(3) amino substituted isoindolinones.

    • Author Affiliations

       

      H SURYA PRAKASH RAO1 J PRABHAKARAN SILAMBARASAN KANNIYAPPAN A VEERA BHADRA RAO

      1. Department of Chemistry, Pondicherry University, Puducherry 605 014, India

    • Dates

       
      Published
      June 2018
      Manuscript received
      8 January 2018
      Manuscript revised
      22 April 2018
      Accepted
      25 April 2018

    • Supplementary Material

       

  • Journal of Chemical Sciences | News

© 2022-2023 Indian Academy of Sciences, Bengaluru.

Contact | Site index