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    • Keywords

       

      Isoindolinones; copper catalysis; deformylative C-N coupling; phenylboronic acid.

    • Abstract

       

      Copper(I) iodide efficiently catalyzes deformylative C-N coupling of formamides and isoindolinone3-ols to provide C(3) primary/secondary amine substituted isoindolinones. The transformation requires a stoichiometric amount of phenylboronic acid as a co-reactant. In the reaction, formamides act as the synthetic equivalent of primary/secondary amines. The method is amenable for the synthesis of a combinatorial library of medicinally relevant C(3) amino substituted isoindolinones.

    • Author Affiliations

       

      H SURYA PRAKASH RAO1 J PRABHAKARAN SILAMBARASAN KANNIYAPPAN A VEERA BHADRA RAO

      1. Department of Chemistry, Pondicherry University, Puducherry 605 014, India
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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