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      https://www.ias.ac.in/article/fulltext/jcsc/130/06/0070

    • Keywords

       

      Copper; alkynones; hydroamination; Michael addition; enaminones.

    • Abstract

       

      An efficient strategy for the synthesis of α,β-unsaturated enaminones by the nucleophilic addition of N-heterocycles such as indole and imidazoles onto electronically bias alkynones under mild reaction conditions is described. Key feature of this reaction is the chemoselective addition of N-heterocycles onto ynones without affecting the 1° amino groups (aromatic and aliphatic) of 5-aminoindole and tryptamine. The stereochemistry of the products was controlled by the tuning of reaction time. The mechanism of the reaction involves the Michael type addition of N-heterocycles on ynones via allene formation.

    • Author Affiliations

       

      MONIKA PATEL SUSHMITA AKHILESH KUMAR VERMA1

      1. Synthetic Organic Chemistry Research Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India
    • Dates

       
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