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      https://www.ias.ac.in/article/fulltext/jcsc/130/06/0069

    • Keywords

       

      Biginelli; β-Ketonitrile; dihydropyrimidin; aldol; aldehyde; urea.

    • Abstract

       

      A Biginelli reaction of β-ketonitriles, aldehydes and urea in principle can yield 5-cyano substituted dihydropyrimidinones. Although potentially very useful, this substituted heterocycle is often difficult to synthesize via the three component reaction, presumably due to the lack of stability of β-ketonitriles. The presentwork describes the development of reaction conditions yielding the desired product. Interesting mechanistic observations have also been noted. Thirteen new compounds (derivatives) of 5-cyanodihydropyrimidin were synthesized.

    • Author Affiliations

       

      SHARAD S PACHORE1 2 NARENDRA B AMBHAIKAR1 VIDAVALUR SIDDAIAH2 SANDIP R KHOBARE1 SARVESH KUMAR1 VILAS H DAHANUKAR1 U K SYAM KUMAR3

      1. Integrated Product Development Organization, Dr. Reddy’s Laboratories Ltd., Innovation Plaza, Bachupally, Telangana 500 072, India
      2. Department of Organic Chemistry, Food, Drugs and Water, Andhra University, Visakhapatnam, Andhra Pradesh 530 003, India
      3. Research Center II, Aurobindo Pharmaceutical Limited, Pashamylaram, Hyderabad, Telangana 502 307, India
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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