1. Home
    2. Journals
    3. Journal of Chemical Sciences
    4. Volume 130
    5. Issue 5

    • Convenient two-step one-pot synthesis of 3-substituted imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines

      Hongli Fan Fenghai Li

      Volume 130 Issue 5 May 2018 Article ID 0055

    • Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/130/05/0055

    • Keywords

       

      Imidazo[1, 2-a]pyridine, imidazo[1, 2-b]pyridazine, heterocyclic amine, active electrophiles

    • Abstract

       

      A convenient and novel two-step one-pot method for the synthesis of 3-substituted imidazo[1,2-a]pyridines and 3-substituted imidazo[1,2-b]pyridazines was developed through the reaction of heterocyclic amines and N, N-dimethylformamide dimethyl acetate with active electrophiles RCH2Br (R=CO2Et, CN, COPh, 4'-MeO-PhCO and 4'-F-PhCO). This protocol provides a simple and practical approach to 3-substituted fused imidazo-heterocyclic compounds in moderate to high yields

    • Author Affiliations

       

      Hongli Fan1 Fenghai Li1

      1. School of Chemistry and Chemical Engineering, Heze University, Heze,China

    • Dates

       
      Published
      May 2018
      Manuscript received
      4 January 2018
      Manuscript revised
      9 April 2018
      Accepted
      10 April 2018

    • Supplementary Material

       

  • Journal of Chemical Sciences | News

© 2022-2023 Indian Academy of Sciences, Bengaluru.

Contact | Site index