• Convenient two-step one-pot synthesis of 3-substituted imidazo[1,2-a]pyridines and imidazo[1,2-b]pyridazines

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    • Keywords


      Imidazo[1, 2-a]pyridine, imidazo[1, 2-b]pyridazine, heterocyclic amine, active electrophiles

    • Abstract


      A convenient and novel two-step one-pot method for the synthesis of 3-substituted imidazo[1,2-a]pyridines and 3-substituted imidazo[1,2-b]pyridazines was developed through the reaction of heterocyclic amines and N, N-dimethylformamide dimethyl acetate with active electrophiles RCH2Br (R=CO2Et, CN, COPh, 4'-MeO-PhCO and 4'-F-PhCO). This protocol provides a simple and practical approach to 3-substituted fused imidazo-heterocyclic compounds in moderate to high yields

    • Author Affiliations


      Hongli Fan1 Fenghai Li1

      1. School of Chemistry and Chemical Engineering, Heze University, Heze,China
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  • Journal of Chemical Sciences | News

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