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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/130/04/0041

    • Keywords

       

      Modified Friedländer reaction; benzoquinoline-carbazoles; pseudo multicomponent reaction; carbazole substituted pyridocarbazole.

    • Abstract

       

      A one-pot, solvent-free protocol for the synthesis of chloro-substituted benzoquinoline-carbazole derivatives via a modified Friedländer hetero-annulation reaction between 2, 3, 4, 9-tetrahydrocarbazol-1-one and 3-amino-2-naphthoic acid in the presence of POCl3 is described. In addition, the direct pseudo multicomponent transformation of 2, 3, 4, 9-tetrahydrocarbazol-1-one, malononitrile and 9-ethyl-3-carbazolecarboxaldehyde results in the formation of a multifunctionalized carbazole through a Knoevenagel–Michael addition-cyclizationreaction has also been reported. All the newly synthesized molecules were deduced by spectral and analytical methods

    • Author Affiliations

       

      KRIPALAYA RATHEESH ARYA1 HAZEL A SPARKES2 KARNAM JAYARAM PILLAI RAJENDRA PRASAD1

      1. Department of Chemistry, Bharathiar University, Coimbatore, Tamilnadu 641 046, India
      2. School of Chemistry, University of Bristol, Cantock’s Close, Bristol BS8 1TS, UK

    • Dates

       
      Published
      April 2018
      Manuscript received
      1 November 2017
      Manuscript revised
      3 January 2018
      Accepted
      23 January 2018

    • Supplementary Material

       

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