• Synthesis, characterisation, nuclease and cytotoxic activity of phosphate-free and phosphate-containing copper 4'-(N-methylpyridinium)-2,2':6' ,2'' terpyridine complexes

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    • Keywords

       

      Pyridinium terpyridine; X-ray structures; DNA cleavage; cytotoxic activity.

    • Abstract

       

      Mononuclear Cu(II) pyridinium terpyridine based compounds, viz., [Cu(q- pytpy)(I)(CH3COO)](I)·(2H2O) (1) and [Cu(dipp)(dippH)(q-pytpy)]·(2H2O)(DMF) (2) were isolated by reacting Cu(OAc)2·H2O with 4'-(N-methylpyridinium)-2,2':6',2''-terpyridine (q-pytpy) in the presence of 2,6 diisopropylphenyl phosphate(dippH2). Both the new compounds were isolated as single crystals and characterised by spectroscopic (IR,ESI-MS, EPR, UV–Vis), thermogravimetric and microanalytical techniques. The molecular structures of both the compounds were determined in the solid-state by single crystal X-ray diffraction studies. Complexes 1 and 2 were evaluated for their nuclease and in vitro anti-tumor activities against human breast and colorectal cancer cell lines. The DNA cleavage and cytotoxic assays revealed that both 1 and 2 are effective in cleaving DNA, while the cytotoxic activity of 1 is better than 2 in both human colon and breast cancer cell lines.

    • Author Affiliations

       

      GULZAR A BHAT1 RAIHANA MAQBOOL2 RAMASWAMY MURUGAVEL1

      1. Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400 076, India
      2. Department of Biotechnology, University of Kashmir, Srinagar 190 006, India
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