• Sodium dichloroiodate promoted C-C bond cleavage: An efficient synthesis of 1,3-Benzazoles via condensation of o-amino/mercaptan/hydroxyanilines with β-diketones

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      https://www.ias.ac.in/article/fulltext/jcsc/130/01/0010

    • Keywords

       

      Benzimidazole/benzothiazole/benzoxazole; β-diketones; NaICl2; C-C bond cleavage

    • Abstract

       

      An efficient aqueous sodium dichloroiodate (NaICl2) mediated protocol is developed for the synthesis of benzofused azoles by the cyclization of 2-amino anilines/thiophenols/phenols with β-diketone compounds. The reactions gave moderate to good yield of the corresponding 2-substituted benzimidazoles/benzothiazoles/benzoxazoles under mild conditions. This tandem process involved a C-C bond cleavage and C-N bond formation.

    • Author Affiliations

       

      SAKET B BHAGAT SHRIKANT M GHODSE VIKAS N TELVEKAR1

      1. Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai, Maharashtra 400 019, India
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  • Journal of Chemical Sciences | News

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