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      https://www.ias.ac.in/article/fulltext/jcsc/130/01/0006

    • Keywords

       

      Molecular hybridization strategy; click reaction; sulfonamide; antiproliferative

    • Abstract

       

      Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. The target sulfonamide hybridswere obtained in the click reaction of azide derivatives and commerciallly available alkynes. All sulfonamide hybrids were evaluated for their antiproliferative activity against three selected cancer cell lines (MGC-803, EC-109 and PC-3). Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. Particularly, compound 8c showed the potent antiproliferative activity withan IC50 value of 0.7μmol against MGC-803 cancer cells. These sulfonamide hybrids might be promising lead compounds to develop antitumor agents in the clinical practice

    • Author Affiliations

       

      DONG-JUN FU1 2 3 4 YU-HUI HOU1 2 3 4 SAI-YANG ZHANG5 YAN-BING ZHANG1 2 3 4

      1. New Drug Research & Development Center, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China
      2. Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, Henan Province, China
      3. Key Laboratory of Technology of Drug Preparation (Zhengzhou University), Ministry of Education, Zhengzhou, China
      4. Key Laboratory of Henan Province for Drug Quality and Evaluation, Zhengzhou, China
      5. School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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