• Advances in trifluoromethylation or trifluoromethylthiolation with copper CF₃ or SCF₃ complexes

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      https://www.ias.ac.in/article/fulltext/jcsc/129/12/1795-1805

    • Keywords

       

      Trifluoromethylation; trifluoromethylthiolation; copper complexes; aryl halides; heteroaryl bromides.

    • Abstract

       

      The copper CF₃ or SCF₃ complexes as the fluoride sources for the synthesis of trifluoromethylated or trifluoromethylthiolated compounds are reviewed. Compared with the ordinary fluoride reagents, the addition of reactant species in the reaction systems of copper trifluoromethyl or trifluoromethylthio complexes were less, so the reaction systems are relatively simple and easy to operate. In most cases, the trifluoromethylated or trifluoromethylthiolated products were obtained in moderate to excellent yields.

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  • Journal of Chemical Sciences | News

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