• Insight into solid-liquid phase transfer catalyzed synthesis of Mecoprop ester using K₂CO₃ as base and development of new kinetic model involving liquid product and two solid co-products

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      https://www.ias.ac.in/article/fulltext/jcsc/129/11/1677-1685

    • Keywords

       

      Phase transfer catalysis; O-alkylation; mecoprop ester; kinetic modelling; solid-liquid reaction.

    • Abstract

       

      2-Methyl-4-chlorophenoxy propionic acid (Mecoprop) is a widely used household herbicide. In the current work, a simple synthetic method is developed for Mecoprop methyl ester using solid-liquid phase transfer catalysis (S-L PTC) with K₂CO₃ as mild base and toluene as solvent. Conversion of 95% was achieved with 100% selectivity for Mecoprop ester at 100 ◦C. Simple isolation process was employed to recover the product from the reaction mixture. A reaction mechanism was proposed and new kinetic model developed involving one liquid and two solid co-products. The activation energy for the reaction was calculated. This is the first example of its kind being reported vis-à-vis kinetics and mechanism.

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  • Journal of Chemical Sciences | News

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