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      https://www.ias.ac.in/article/fulltext/jcsc/129/10/1627-1637

    • Keywords

       

      Copper(II); crystal structure; phenoxazinone synthase activity; catechol dioxygenase; bio-mimetic chemistry.

    • Abstract

       

      A coper(II) complex, [Cu(dpa)2(OAc)](ClO4) (1) [dpa =2, 2'-dipyridylamine; OAc = acetate], has been synthesized and crystallographically characterized. X-ray structure analysis revealed that this mononuclear Cu(II) complex crystallizes as a rare class of hexa coordination geometry named bicapped square pyramidalgeometry with P2₁/c space group. This copper complex displays excellent catalytic efficiency, kcat /KM (h⁻¹) = 6.17 × 10⁵ towards the oxidative coupling of 2-aminophenol (2-AP) to aminophenoxazin-3-one. Further, upon stoichiometric addition of copper(II) complex to 3,5-DTBC in presence of molecular oxygen in ethanol medium, the copper complex affords predominantly extradiol cleavage products along with a small amount of benzoquinone and a trace amount of intradiol cleavage products at a rate, kobs = 1.09 × 10⁻³ min ⁻¹, which provide substantial evidence for the oxygen activation mechanism. This paper presents a novel addition of a copper(II) complex having the potential to mimic the active site of phenoxazinone synthase and catechol dioxygenase enzymes with significant catalytic efficiency.

    • Author Affiliations

       

      BISWAJIT CHOWDHURY1 MILAN MAJI2 BHASKAR BISWAS1 3

      1. Department of Chemistry, Raghunathpur College, Purulia, West Bengal 723 133, India
      2. Department of Chemistry, National Institute of Technology, Mahatma Gandhi Avenue, Durgapur,West Bengal 713 209, India
      3. Department of Chemistry, Surendranath College, 24/2 M G Road, Kolkata, West Bengal 700 009, India
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