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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/10/1603-1610

    • Keywords

       

      Stereoselective aminocatalysis; monofunctional amine; d-fructose; Michael addition; nitroalkene.

    • Abstract

       

      Organocatalytic asymmetric Michael addition is considered among the most extensively studied, yet challenging stereoselective reactions due to the fact that the electrophilic prochiral carbon in Michael acceptor lies away from stereodirecting groups of the catalyst. Although there is a report on stereoselective organocatalysis in Michael addition employing monofunctional secondary amine, the use of monofunctional primary amine forthe said reaction is not reported till date. In fact, no monofunctional aminocatalyst is reported yet for the synthesis γ-nitro carbonyl compounds. Here we report our preliminary results on the enantioselective Michael addition of different ketones to nitro olefins catalysed by monofunctional primary amine (1) derived from d-fructose.

    • Author Affiliations

       

      KHIANGTE VANLALDINPUIA1 2 PORAG BORA1 GRACE BASUMATARY1 RAHUL MOHANTA1 GHANASHYAM BEZ1

      1. Department of Chemistry, North Eastern Hill University, Shillong, Meghalaya 793 022, India
      2. Department of Chemistry, Pacchunga University College, Aizawl, Mizoram 796 001, India

    • Dates

       
      Published
      23 October 2017
      Manuscript received
      31 July 2017
      Manuscript revised
      24 August 2017
      Accepted
      3 September 2017

    • Supplementary Material

       

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