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      https://www.ias.ac.in/article/fulltext/jcsc/129/10/1549-1557

    • Keywords

       

      (E)-3-(3-arylacryloyl)-2H-chromen-2-ones; ethyl 2-nitroacetate; 6-(2-oxo-2H-chromen-3-yl)-4- arylpyridin-2(1H)-ones; anti-bacterial; anti-fungal.

    • Abstract

       

      An expedient synthesis of coumarin-pyridone conjugate molecules 2a-o is reported via one-pot reaction between (E)-3-(3-arylacryloyl)-2H-chromen-2-ones 1a-o, ethyl 2-nitroacetate and ammonium acetate. The structures of synthesized compounds have been unambiguously confirmed by spectroscopic analyses (NMR, IR and MS). All the compounds were screened for their anti-microbial activities against three Gram-positive bacterial strains, two Gram-negative bacterial strains and four fungal organisms. Compounds 2d, 2i, 2k, 2oexhibited mild anti-bacterial activity and 2d, 2m were found to be moderately active against all the tested fungal organisms. Compound 2k showed good inhibitory potential against the tested yeasts organisms.

    • Author Affiliations

       

      RAJNI KHAJURIA1 2 SHEENA MAHAJAN1 AMBICA 3 KAMAL K KAPOOR1

      1. Department of Chemistry, University of Jammu, Jammu, Jammu and Kashmir 180 006, India
      2. Department of Chemistry and Chemical Sciences, Central University of Jammu, Jammu, Jammu and Kashmir, India
      3. Department of Chemistry, Government Degree College, Kathua, Jammu and Kashmir 184 101, India
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  • Journal of Chemical Sciences | News

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