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      https://www.ias.ac.in/article/fulltext/jcsc/129/09/1423-1430

    • Keywords

       

      Hydrolysis; Cu& #178; & #8314; ions; rhodamine-B; cell imaging.

    • Abstract

       

      Anewrhodamine-based Schiff base (L) has been synthesized and characterized by physicochemical and spectroscopic tools. This organic molecule selectively reacts with Cu²⁺ ions with a remarkably significant optical change, which supports the development of a chemosensor for Cu²⁺ ions as low as nanomolar level in aqueous medium. On the basis of the experimental work, the ‘turn-on’ colorimetric/fluorimetric spectroscopic change is due to Cu²⁺ ion-assisted hydrolysis followed by spirolactam ring opening of the probe (L) in 20mM HEPES buffer [pH 7.4; water/acetonitrile (9:1 v/v)]. The competitive ions do not affect the selectivity and specificity of the probe (L) in the detection of Cu²⁺ ions. The cell imaging study using fluorescence microscope showed that this non-cytotoxic probe is useful to detect the distribution of Cu²⁺ ions in AGS cells lines.

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  • Journal of Chemical Sciences | News

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