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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/08/1257-1266

    • Keywords

       

      Phthalazinesulfonamide; aldehyde; dimedone; sulfonated diatomite; heterogeneous catalyst.

    • Abstract

       

      Several phthalazine derivatives were synthesized by the one-pot three-component condensation in good to high yields in the presence of diatomite-SO3H as a solid acid catalyst. Then, a series (n=14) of phthalazine sulfonamides were synthesized by the reaction phthalazine sulfonyl chloride and various amines under solvent-free conditions. The prepared compounds were screened for antibacterial activity against Escherichia coli (E. coli ATCC 25922) and Staphylococcus aureus (S. aureus ATCC 5213) as gram negative and positive respectively. Also, in silico physicochemical parameters of synthesized compounds were studied to predict absorption and permeability using Molinspiration online property calculation server.

    • Author Affiliations

       

      MARZIEH ABBASI1 2 SEYED MOHAMAD REZA NAZIFI2 ZAHRA SADAT NAZIFI1 3 AHMAD REZA MASSAH1 3

      1. Department of Chemistry, Islamic Azad University, Shahreza Branch, Shahreza, Isfahan 86145-311, Islamic Republic of Iran
      2. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
      3. Razi Chemistry Research Center, Islamic Azad University, Shahreza Branch, Shahreza, Isfahan 86145-311, Islamic Republic of Iran

    • Dates

       
      Published
      5 August 2017
      Manuscript received
      7 January 2017
      Manuscript revised
      23 May 2017
      Accepted
      31 May 2017

    • Supplementary Material

       

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