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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/08/1247-1256

    • Keywords

       

      Azaphthalocyanine; eugenoe; lipase inhibition; phthalocyanine; DNA interaction

    • Abstract

       

      Novel eugenol-substituted zinc(II) azaphthalocyanines (ZnAzaPcs)were synthesised and their lipase inhibition and DNA binding properties compared with phthalocyanines (Pcs) containing eugenol. This is the first study on lipase inhibition and DNA binding of Pcs and AzaPcs containing a pharmacophore group, such as eugenol. The novel ZnAzaPcs were characterised using a combination of FT-IR, ¹HNMR, ¹³CNMR, UV–Vis, MS and elemental analysis. The crystal structures of two pyrazine compounds were also determined by the single crystal diffraction technique. This study showed that two phthalocyanines compounds (3a and 4a) could be potential lipase inhibitor agents due to greater hydrophobicity than other azaphtalocyanines. Compound 4a displayed lowest IC₅₀ value. Non-intercalative binding to DNA was identified only for compound 2a.

    • Author Affiliations

       

      GÜNAY KAYA KANTAR1 ÖZLEM FAİZ1 ONUR ŞAHİN2 SELAMİ ŞAŞMAZ1

      1. Department of Chemistry, Science and Art Faculty, Recep Tayyip Erdogan University, 53100 Rize, Turkey
      2. Scientific and Technological Research Application and Research Center, Sinop University, 57000 Sinop, Turkey

    • Dates

       
      Published
      5 August 2017
      Manuscript received
      6 December 2016
      Manuscript revised
      27 January 2017
      Accepted
      20 May 2017

    • Supplementary Material

       

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