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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/08/1233-1245

    • Keywords

       

      Chromone; unnatural aminoacids; isoflavones; alkylation; hybrid molecules; glycine derivatives.

    • Abstract

       

      An efficient method for the preparation of chromone based α-amino acid derivatives by alkylation of glycinate schiff base with 3-bromomethyl chromone as well as 2-bromomethyl chromone has been described. Using this method, 2-amino-3-(4-oxo-2-chromenyl)propanoic acid and 2-amino-3-(4-oxo-3- chromenyl)propanoic acid, two novel chromone-amino acid conjugates have been prepared. Furthermore, the separation of chromone amino acid enantiomers by chiral column chromatography was accomplished.

    • Author Affiliations

       

      VENU KANDULA1 2 RAMAKRISHNA GUDIPATI1 ANINDITA CHATTERJEE2 MURALIDARAN KALIYAPERUMALA1 SATYANARAYANA YENNAM1 MANORANJAN BEHERA1

      1. Department of Medicinal Chemistry, GVK Biosciences Pvt. Ltd., Survey No. 125, 126 IDA, Mallapur, Hyderabad, Telangana 500 076, India
      2. Department of Chemistry, K L University, Vaddeswaram, Guntur, Andhra Pradesh 522 502, India

    • Dates

       
      Published
      5 August 2017
      Manuscript received
      23 March 2017
      Manuscript revised
      18 May 2017
      Accepted
      19 July 2017

    • Supplementary Material

       

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