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    • An efficient catalyst-free synthesis of novel chromeno[4,3-b]quinolones through Michael initiated ring closure (MIRC) reaction with in situ generated 3-(arylmethylene)chroman-2,4-diones

      SUDESH KUMARI JITENDER M KHURANA

      REGULAR ARTICLE Volume 129 Issue 8 August 2017 pp 1225-1231

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/08/1225-1231

    • Keywords

       

      Ethylene glycol; 4-hydroxycoumarin; multicomponent reaction; green chemistry

    • Abstract

       

      A catalyst-free multicomponent reaction capable of affording a wide range of eighteen novel chromeno[4,3-b]quinolone derivatives (6a–6r) via one-pot two-step domino protocol, in ethylene glycol is reported. Catalyst-free conditions along with green solvent system make the process eco-friendly as well aseconomical. High yields of the products were obtained in short reaction times by forming three new bonds and one stereocenter in a single operation. The salient features of the present protocol are short reaction times, eco-friendly solvents, high yields and easy work-up procedure.

    • Author Affiliations

       

      SUDESH KUMARI JITENDER M KHURANA

      1. Dates

         
        Published
        5 August 2017
        Manuscript received
        3 November 2016
        Manuscript revised
        8 May 2017
        Accepted
        9 June 2017

      2. Supplementary Material

         

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