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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/08/1205-1209

    • Keywords

       

      Allyl halides; barbier reaction; ecofriendly synthesis; isatin; oxindoles; green synthesis; water-mediated reaction.

    • Abstract

       

      A robust and rapid synthesis of 3-hydroxy-3-alkyl-2-oxindoles from isatins is described. This method introduces an ecofriendly, un-activated Zn dust, solid NH₄Cl and substrates under aqueous conditions, which has produced the product in moderate to good yields. Without using column chromatography, majority of the compounds were isolated in analytically pure form. The progress of the reaction could be visualized by naked eye.

    • Author Affiliations

       

      L RAJU CHOWHAN1 MARRI SAMEER REDDY2 NANDIGAMA SATISH KUMAR1

      1. Centre for Applied Chemistry, Central University of Gujarat, Gandhinagar, Gujarat 382 030, India
      2. School of Chemical Sciences, Central University of Gujarat, Gandhinagar, Gujarat 382 030, India

    • Dates

       
      Published
      5 August 2017
      Manuscript received
      4 March 2017
      Manuscript revised
      22 May 2017
      Accepted
      10 July 2017

    • Supplementary Material

       

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