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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/06/0691-0698

    • Keywords

       

      Multi-component domino reactions (MDRs); one-pot; acetylenic esters; Ph3P; spirofuranindenoquinoxaline.

    • Abstract

       

      A simple and convenient multi-component domino reaction has been described for the synthesis of novel spirofuran-indenoquinoxaline derivatives. Products were obtained by a three-component condensation reaction between ninhydrin, aromatic 1,2-diamines and dialkyl ethynedicarboxylates in the presence of a catalytic amount of triphenylphosphine in CH2Cl2 at ambient temperature in excellent yields. This one-pot process produces biologically and pharmacologically significant heterocycles with the formation of five new bonds (one C–C, two C=N and two C–O) and two new rings in a single operation.

    • Author Affiliations

       

      AFSHIN YAZDANI-ELAH-ABADI1 MALEK-TAHER MAGHSOODLOU1 RAZIEH MOHEBAT2 REZA HEYDARI1

      1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P.O. Box: 98135-674, Zahedan, Iran
      2. Young Researchers and Elite Club, Yazd Branch, Islamic Azad University, Yazd, Iran

    • Dates

       
      Published
      20 June 2017
      Manuscript received
      5 March 2017
      Manuscript revised
      11 April 2017
      Accepted
      19 April 2017

    • Supplementary Material

       

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