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    • Keywords

       

      Iodine; oxidative dehydrogenation; oxoisoaporphines; 1-Azabenzanthrone; isoindoloisoquinolinones.

    • Abstract

       

      A facile and convenient method for the synthesis of substituted 2-(isoquinolin-1-yl)benzoic acids from isoindoloisoquinolinones in the presence of molecular iodine under sealed tube condition at 100◦C has been developed. This methodology involves the oxidative dehydrogenation and ring opening of hydroxylactam/methoxy lactam to furnish the 2-(isoquinolin-1-yl)benzoic acids. Some of these acids are successfully cyclized to furnish the azabenzanthrone derivatives, the potential precursors for the synthesis of menisporphine alkaloids and daurioxoisoaporphines.

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  • Journal of Chemical Sciences | News

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