• Synthesis and comparing the antibacterial activities of pyrimidine derivatives

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      https://www.ias.ac.in/article/fulltext/jcsc/129/03/0335-0341

    • Keywords

       

      5-amino thiadiazole; 5-amino triazole; hydrazine carbothioamide; pseudomonas aeruginosa; staphylococcus aureus; escherichia coli.

    • Abstract

       

      A series of 10 derivatives of 5-(5-amino-1,3,4-thiadiazole-2-yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-one and 10 derivatives of 3,4-dihydro-5-(5-mercapto-4H-1,2,4-triazol-3-yl)-6-methyl-4-phenyl pyrimidin-2(1H)-one have been synthesized. Among the synthesized derivatives, triazole substitutedcompounds have shown higher antibacterial inhibition when compared to the thiadiazole derivatives. All the structures of the newly synthesized compounds have been characterized by IR, 1H and 13C NMR, GC-MS and CHN analysis. Most of the compounds have shown promising antibacterial activity when compared with the standard drug ciprofloxacin.

    • Author Affiliations

       

      B ANDREWS1 2 3 K KOMATHI3 4 S MOHAN3 4

      1. PG and Research Department of Chemistry, Islamiah College, Vaniyambadi 635 752, India
      2. Thiruvalluvar University, Vellore, Tamil Nadu, India
      3. Priyadarshini Engineering College, Vaniyambadi, Tamil Nadu, India
      4. Anna University, Chennai, Tamil Nadu, India
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  • Journal of Chemical Sciences | News

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