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    • Synthesis and comparing the antibacterial activities of pyrimidine derivatives

      B ANDREWS K KOMATHI S MOHAN

      Regular Article Volume 129 Issue 3 March 2017 pp 335-341

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/03/0335-0341

    • Keywords

       

      5-amino thiadiazole; 5-amino triazole; hydrazine carbothioamide; pseudomonas aeruginosa; staphylococcus aureus; escherichia coli.

    • Abstract

       

      A series of 10 derivatives of 5-(5-amino-1,3,4-thiadiazole-2-yl)-3,4-dihydro-6-methyl-4-phenylpyrimidin-2(1H)-one and 10 derivatives of 3,4-dihydro-5-(5-mercapto-4H-1,2,4-triazol-3-yl)-6-methyl-4-phenyl pyrimidin-2(1H)-one have been synthesized. Among the synthesized derivatives, triazole substitutedcompounds have shown higher antibacterial inhibition when compared to the thiadiazole derivatives. All the structures of the newly synthesized compounds have been characterized by IR, 1H and 13C NMR, GC-MS and CHN analysis. Most of the compounds have shown promising antibacterial activity when compared with the standard drug ciprofloxacin.

    • Author Affiliations

       

      B ANDREWS1 2 3 K KOMATHI3 4 S MOHAN3 4

      1. PG and Research Department of Chemistry, Islamiah College, Vaniyambadi 635 752, India
      2. Thiruvalluvar University, Vellore, Tamil Nadu, India
      3. Priyadarshini Engineering College, Vaniyambadi, Tamil Nadu, India
      4. Anna University, Chennai, Tamil Nadu, India

    • Dates

       
      Published
      6 March 2017
      Manuscript received
      29 July 2016
      Manuscript revised
      23 September 2016
      Accepted
      29 December 2016

    • Supplementary Material

       

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