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      https://www.ias.ac.in/article/fulltext/jcsc/129/03/0301-0312

    • Keywords

       

      D-Fructose; primary amine; monofunctional organocatalyst; asymmetric aldol.

    • Abstract

       

      A new class of organocatalysts involving a primary amine as the only functional group is developed for catalytic asymmetric aldol reaction of cyclohexanone/ cyclopentanone with various aryl aldehydes in thepresence of benzoic acid as an additive at −10◦C. In an unexpected observation, the primary amine catalyzed reactions gave excellent yield and good to excellent stereoselectivity, while secondary amines were found to have little or no reactivity under similar reaction conditions.

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