Monofunctional primary amine: A new class of organocatalyst for asymmetric Aldol reaction
KHIANGTE VANLALDINPUIA PORAG BORA GHANASHYAM BEZ
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A new class of organocatalysts involving a primary amine as the only functional group is developed for catalytic asymmetric aldol reaction of cyclohexanone/ cyclopentanone with various aryl aldehydes in thepresence of benzoic acid as an additive at −10◦C. In an unexpected observation, the primary amine catalyzed reactions gave excellent yield and good to excellent stereoselectivity, while secondary amines were found to have little or no reactivity under similar reaction conditions.
Volume 135, 2023
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