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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/02/0211-0222

    • Keywords

       

      Quaternary ammonium derivatives; triazolyl pyranochromen-2-ones; antibacterial activity; structure-activity relationship (SAR).

    • Abstract

       

      A series of quaternary ammonium derivatives of triazolyl pyranochromen-2-ones have been synthesized and characterized; their antibacterial potential were investigated against two gram negative (Pseudomonas aeruginosa and Escherichia coli) and two gram positive bacterial strains (Bacillus cereus and Staphylococcus aureus). In order to develop structure-activity relationship (SAR), the effect of varying the substituent (R) at the C-10 position of pyranochromen-2-one as well as the length of the spacer (n) between the triazolyl pyranochromen-2-ones and quaternary ammonium group, on the antibacterial activity of compoundshas been evaluated. Some of the screened compounds exhibited antibacterial potential against the studied strains in the microgram range.

    • Author Affiliations

       

      PREETI YADAV1 BIPUL KUMAR2 HEMANT K GAUTAM2 SUNIL K SHARMA1

      1. Department of Chemistry, University of Delhi, Delhi 110 007, India
      2. CSIR-Institute of Genomics and Integrative Biology, Sukhdev Vihar, Mathura Road, Delhi 110 025, India
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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