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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/02/0203-0210

    • Keywords

       

      Chan-Lam coupling; quinazoline; boronic acids; copper acetate.

    • Abstract

       

      An efficient method for the synthesis of S-aryl/heteroaryl-quinazoline has been developed through the cross-coupling of 1,4-dihydroquinazoline with a variety of aryl and heteroaryl boronic acids assisted by [Cu(OAc)₂] as the catalyst for the formation of carbon-sulfur bonds. This newly developed method demonstratesthat the conditions of the traditional copper-catalyzed Chan-Lam reaction can be improved. Optimized reaction involves base, solvent and catalyst.

    • Author Affiliations

       

      SATYA KARUNA PULAKHANDAM1 NARESH KUMAR KATARI2 RAVI PRAKASH REDDY MANDA3

      1. Jawaharlal Nehru Technological University Kakinada, Kakinada 533 003, Andhra Pradesh, India
      2. Department of Chemistry, GITAM School of Technology, GITAM University, HTP campus, Rudraram, Medak 502 329, Telangana, India
      3. C-MET, IDA Phase II, Cherlapally, HCL (PO), Hyderabad 500 051, Telangana, India
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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