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    • One-pot Reductive Amination of Carbonyl Compounds with NaBH₄-B(OSO₃H)₃/SiO₂ in Acetonitrile and in Solvent-free Condition

      HOSEIN HAMADI SAMIRA JAVADI

      Regular Article Volume 129 Issue 1 January 2017 pp 75-80

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/129/01/0075-0080

    • Keywords

       

      Reductive amination; boron trisulfunic acid; catalysis; NaBH& #8324; .

    • Abstract

       

      An efficient one-pot procedure for the direct reductive amination of aldehyde and ketones was achieved in the presence of sodium borohydride by using B(OSO₃H)₃/SiO₂(SBSA) as the reusable solid catalyst in acetonitrile and solvent-free conditions. Both aromatic and aliphatic aldehyde reacted well to give the corresponding amines in excellent yields. All the products are known and well-characterized. The catalyst is recoverable and could be easily recycled by filtration and reused several times without any significant loss of its activity. SBSA acts as a dual Brønsted/Lewis acid that is an air-stable and cost-effective solid acid.

    • Author Affiliations

       

      HOSEIN HAMADI SAMIRA JAVADI

      1. Dates

         
        Published
        5 January 2017
        Manuscript received
        6 August 2016
        Manuscript revised
        9 November 2016
        Accepted
        9 November 2016

      2. Supplementary Material

         

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