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      https://www.ias.ac.in/article/fulltext/jcsc/129/01/0045-0055

    • Keywords

       

      Cadmium(II) complex; carboxamide ligand; crystal structures; DNA binding study.

    • Abstract

       

      Treatment of perchlorate or nitrate salt of cadmium(II) with carboxamide derivatives (L) generated four novel mononuclear metal complexes, represented as [Cd(L)₄](ClO₄)₂ (1a and 1b) and [Cd(L)₂(ONO₂)₂] (2a and 2b) in appreciable yields (L = L¹ = N-(furan-2-ylmethyl)-2-pyridine carboxamide and L = L² = N-(thiophen-2-ylmethyl)-2-pyridine carboxamide). The complexes have been characterized by FT-IR, UVVisible, elemental analysis and single crystal X-ray crystallographic analysis which revealed eight coordinated cadmium ions, but in different coordination environments, depending on the counter anion used. In addition,electronic absorption, fluorescence spectroscopy and viscosity measurements revealed a significant interaction of the four complexes with CT-DNA via intercalative/groove binding mode. The intrinsic binding constant Kbobtained varies from 0.4 × 10⁴ to 1.11 × 10⁵ M⁻¹. The results suggest that neutral complexes 2a and 2b bind to DNA in an intercalative mode. On the other hand, cationic complexes 1a and 1b bind with DNA via weak electrostatic/covalent interaction.

    • Author Affiliations

       

      BIPLAB MONDAL1 BUDDHADEB SEN1 SANDIPAN SARKAR1 ENNIO ZANGRANDO2 PABITRA CHATTOPADHYAY1

      1. Department of Chemistry, Burdwan University, Golapbag, Burdwan, West Bengal 713 104, India
      2. Department of Chemical and Pharmaceutical Sciences, Via Licio Giorgieri 1, 34127 Trieste, Italy
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    • Supplementary Material

       
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