• Studies towards C-3 functionalization of β-lactams using substituted allylsilanes

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      https://www.ias.ac.in/article/fulltext/jcsc/128/11/1745-1753

    • Keywords

       

      Allylsilane; & #946; -Lactams; Lewis acid; desulphurisation; crotylsilane; cinnamylsilane.

    • Abstract

       

      An effective and stereoselective synthesis of 3-(1'-methyl/phenylallyl)-3-phenylthio-β-lactams (3/4) using substituted allylsilane and Lewis acid is described. The reaction leads to the formation of a mixture of C-3 substituted allyl β-Lactams. However, these compounds on desulphurisation using tri-n-butyltinhydride and Raney Ni provide two separable diastereomers of the reduced product.

    • Author Affiliations

       

      RENU THAPAR1 RESHMA 2 S S BARI3

      1. U I ET, Panjab University, Chandigarh 160014, India
      2. D A V College, Sector 10, Chandigarh 160010, India
      3. Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India
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  • Journal of Chemical Sciences | News

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