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    • Studies towards C-3 functionalization of β-lactams using substituted allylsilanes

      RENU THAPAR RESHMA S S BARI

      Regular Article Volume 128 Issue 11 November 2016 pp 1745-1753

    • Fulltext

       

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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/128/11/1745-1753

    • Keywords

       

      Allylsilane; & #946; -Lactams; Lewis acid; desulphurisation; crotylsilane; cinnamylsilane.

    • Abstract

       

      An effective and stereoselective synthesis of 3-(1'-methyl/phenylallyl)-3-phenylthio-β-lactams (3/4) using substituted allylsilane and Lewis acid is described. The reaction leads to the formation of a mixture of C-3 substituted allyl β-Lactams. However, these compounds on desulphurisation using tri-n-butyltinhydride and Raney Ni provide two separable diastereomers of the reduced product.

    • Author Affiliations

       

      RENU THAPAR1 RESHMA 2 S S BARI3

      1. U I ET, Panjab University, Chandigarh 160014, India
      2. D A V College, Sector 10, Chandigarh 160010, India
      3. Department of Chemistry and Centre of Advanced Studies in Chemistry, Panjab University, Chandigarh 160014, India

    • Dates

       
      Published
      2 November 2016
      Manuscript received
      17 April 2016
      Manuscript revised
      1 August 2016
      Accepted
      17 August 2016

    • Supplementary Material

       

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