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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/128/09/1445-1449

    • Keywords

       

      Triazole; benzotriazinone; diazonium chemistry; nanocatalyst; acetylcholinesterase.

    • Abstract

       

      An approach for the construction of benzotriazinone-triazole system is described. The synthesis is based on diazonium chemistry and subsequent intramolecular heteroatom-heteroatom bond formation. The introduction of triazole moiety occurred via click reaction catalyzed by nano-sized copper, supported on modified silica mesopore KIT-5 leading to the desired products in excellent yield. Also, in vitro acetylcholinesterase(AChE) inhibitory activities of the target compounds were screened by Ellman’s method.

    • Author Affiliations

       

      SETAREH MOGHIMI1 FERESHTEH GOLI-GARMROODI1 HEDIEH PILALI1 MOHAMMAD MAHDAVI2 LOGHMAN FIROOZPOUR2 HAMID NADRI3 ALIREZA MORADI3 ALI ASADIPOUR4 ABBAS SHAFIEE1 ALIREZA FOROUMADI1 2

      1. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
      2. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
      3. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
      4. Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

    • Dates

       
      Published
      1 September 2016
      Manuscript received
      15 March 2016
      Manuscript revised
      23 July 2016
      Accepted
      28 July 2016

    • Supplementary Material

       

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