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https://www.ias.ac.in/article/fulltext/jcsc/128/08/1321-1325

Oxidation; sulfide; sulfoxide; sulfone; benzimidazole anthelmintic

An improved green route has been developed for the oxidation of sulfide compounds. Albendazole is converted to ricobendazole or albendazole sulfone using H₂O₂ as an oxidant and H₂O as the solvent. High yields of the corresponding products were obtained by carrying out the reaction at room temperature. This synthetic method is environmentally clean and safe, operationally simple for the oxidation of other benzimidazole anthelmintics and various sulfide compounds.

RAVINDRA B WAGH SITARAM H GUND JAYASHREE M NAGARKAR

Published

1 August 2016

Manuscript received

22 March 2016

Manuscript revised

11 May 2016

Accepted

24 May 2016

• JCSC_128_8_1321_1325_SI.docx