• Titanocene(III) chloride mediated radical induced addition-elimination route to the synthesis of racemic and optically active trisubstituted tetrahydrofurans: Formal synthesis of magnofargesin and 7'-epimagnofargesin

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    • Keywords

       

      Titanocene(III) chloride; radical; tetrahydrofurans; synthesis; furano lignans.

    • Abstract

       

      Titanocene(III) Chloride mediated radical induced synthesis of 4-benzylidene substituted tetrahydrofuran, a typical lignan skeleton, has been accomplished in good yield through addition-elimination route in racemic as well as in optically active forms. The method has been applied to the synthesis of furano lignans, magnofargesin (1) and 7'-epimagnofargesin (2) in optically active forms.

    • Author Affiliations

       

      P CHAKRABORTY1 S K MANDAL2 S C ROY1

      1. Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, India
      2. Department of Chemistry, Saldiha College, Saldiha, Bankura 722 173, India
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