• Fulltext

       

        Click here to view fulltext PDF


      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/128/06/0929-0939

    • Keywords

       

      Anticancer activity; cyclopropane; carbohydrazides; 2-furfuraldehyde.

    • Abstract

       

      The synthesis of novel series of cyclopropane carbohydrazides is described via Knoevenagel condensationof 2-furfuraldehyde with malonic acid in five steps. Condensation of the key intermediate 2-(furan-2-yl)cyclopropanecarbohydrazide (4) with heteroaryl/aryl aldehydes (a-t) in presence of ZnO NP in ethanolresulted in substituted N- hetero/arylidene-2-(furan-2-yl) cyclopropane carbohydrazides (5a-t). These compoundswere screened for their anticancer activity against a panel of four cancer cell lines and four compoundsshowed promising activity at micromolar concentration against all the tested cell lines with IC50 values rangingbetween 1.9-8.45μM. These compounds were further validated with in silico methods at the anticancer target,colchicine binding site.

    • Author Affiliations

       

      PONNAPALLI VEERABHADRA SWAMY1 2 PULLAIAH CHINA KAMBHAMPATI1 KOTHAPALLI BONNOTH CHANDRASEKHAR3 GUGULOTHU THIRUPATHI2 POMBALA SUJITHA4 CHITYAL GANESH KUMAR4 VEERAMACHANENI GANESH KUMAR5

      1. Laxai Avanti Life Sciences, Lab#9, ICICI Knowledge Park, Shameerpet, Turkapally Village, Hyderabad, Telengana, 500 078, India
      2. Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Hyderabad, Telangana, 500 085, India
      3. Department of Chemistry, Jawaharlal Nehru Technological University Anantapuramu, College of Engineering Anantapur, Andhra Pradesh, 500 085, India
      4. Medicinal Chemistry and Pharmacology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 007, India
      5. Department of Biotechnology, K L E F University, Green Fields, Vaddeswaram, Guntur (Dt.), Andhra Pradesh, 522 502, India
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

© 2021-2022 Indian Academy of Sciences, Bengaluru.