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      https://www.ias.ac.in/article/fulltext/jcsc/128/05/0815-0824

    • Keywords

       

      Sulfonamide; Cu(II) complexes; crystal structure; oxidative DNA cleavage; cytotoxic activity.

    • Abstract

       

      A new N-sulfonamide ligand (HL1= N-(5-(4-methoxyphenyl)-[1,3,4]–thiadiazole–2-yl)-toluenesulfonamide)and two Cu(II) complexes, $[Cu(L1)_{2}(py)_{2}]$ (C1) and $[Cu(L2)_{2}(py)_{2}(H_{2}O)]$ (C2) (HL2 = N-(5-(4-methylphenyl)-[1,3,4]–thiadiazole–2-yl)-benzenesulfonamide) were synthesized. The X-ray crystal structuresof the complexes were determined. In the complex C1, the Cu(II) ion is four-coordinated, forming a $CuN_{4}$ chromophore and in the complex C2, the Cu(II) ion is five-coordinated, forming a $CuN_{4}O$ chromophore. Theligand acts as monodentate, coordinating the Cu(II) ion through a single $N_{thiadiazole}$ atom. The molecules fromthe reaction medium (pyridine and water) are also involved in the coordination of the Cu(II) ion. The complexesC1 and C2 are square-planar and a slightly distorted square pyramidal, respectively. The compounds werecharacterized by FT-IR, electronic, EPR spectroscopic and magnetic methods. The nuclease binding activitystudies of the synthesized complexes confirm their capacity to cleave the DNA molecule. The cytotoxicitystudies were carried out on melanoma cell line WM35 which confirm that both compounds inhibit the growthof these cells. They have a higher activity compared to a platinum drug, carboplatin.

    • Author Affiliations

       

      ADRIANA CORINA HANGAN1 ALEXANDRU TURZA2 ROXANA LIANA STAN3 BOGDAN SEVASTRE4 EMÖKE PÁLL4 SÎNZIANA CETEAN1 LUMINI¸TA SIMONA OPREAN1

      1. Department of Inorganic Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy, Cluj-Napoca 4000012, Romania
      2. National Institute for R&D of Isotopic and Molecular Technologies, Cluj-Napoca 400293, Romania
      3. Department of Pharmaceutical Biochemistry and Clinical Laboratory, Faculty of Pharmacy, University of Medicine and Pharmacy, Cluj-Napoca 4000012, Romania
      4. Paraclinic/Clinic Department, Faculty of Veterinary Medicine, University of Agricultural Science and Veterinary Medicine, Cluj-Napoca 400372, Romania
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    • Supplementary Material

       
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