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      Permanent link:
      https://www.ias.ac.in/article/fulltext/jcsc/128/05/0787-0802

    • Keywords

       

      Pyranoindolones; positional isomers; gold catalysis; chemical synthesis; cytotoxicity; molecular docking.

    • Abstract

       

      A hybrid pharmacophore approach for the synthesis of isomeric pyranoindolones was achievedby employing gold(III) chloride-catalyzed cycloisomerization of alkyne-tethered indole carboxylic acids ingood to excellent yield. All the synthesized compounds were evaluated for their tumor cell growth inhibitoryactivity against human cervix adenocarcinoma (HeLa) which revealed that three compounds exhibited activitycomparable with the standard cis-platin $(IC_{50} = 0.μM)$. Molecular docking of all the compounds in Vaccinia H1-Related (VHR) Phosphatase receptor also supported that compound 7d as the most active with a free energyof binding as - 8.27 kcal/mol.

    • Author Affiliations

       

      J C JEYAVEERAN1 CHANDRASEKAR PRAVEEN2 Y ARUN3 A A M PRINCE1 P T PERUMAL3

      1. Department of Chemistry, Ramakrishna Mission Vivekananda College, Mylapore, Chennai 600 004, India
      2. Functional Materials Division, Central Electrochemical Research Institute (CSIR laboratory), Karaikudi 630 006, India
      3. Organic Chemistry Division, Central Leather Research Institute (CSIR laboratory), Adyar, Chennai 600 020, India
    • Dates

       
    • Supplementary Material

       
  • Journal of Chemical Sciences | News

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